Ketamine & SPRAVATO® · Review
The Best Ketamine & SPRAVATO® Clinics in Denver: 2026 Review
By the Depression Treatment Answers publication team · Reviewed against our published methodology · Updated October 2026
Ketamine-based depression treatment in the Denver metro spans two related paths — supervised generic ketamine (typically self-pay, off-label) and FDA-approved SPRAVATO® (esketamine), delivered in certified centers and commonly insurance-covered — and the metro has credible providers across both. We reviewed them using our published criteria, with particular weight in this category on supervision model (in-clinic, monitored care), physician leadership, whether both ketamine pathways are available, insurance access for the covered pathway, and ease of getting started. Every clinic listed is a legitimate provider; the ranking reflects comparison on those criteria. Where a listed clinic shares ownership with this publication, that relationship is disclosed at the listing itself and on our disclosure page.
1.TMS Therapy Centers ColoradoAurora
Disclosure: TMS Therapy Centers Colorado shares ownership with this publication. See our full disclosure.
The metro's most complete single-roof option for this category: a certified SPRAVATO® treatment center and a provider of medically supervised ketamine therapy, inside a physician-led clinic founded by board-certified psychiatrist Dr. William Kromka, MD — with psychiatric evaluation, medication management, and FDA-cleared TMS alongside. That combination matters practically: a patient can be evaluated once and matched to the covered SPRAVATO® pathway, supervised ketamine, or a different modality entirely, without changing clinics. Most major insurance is accepted including Medicare, benefits are verified before treatment, consultations are free, and the clinic answers at 720-500-7873, serving Aurora, Denver, and the Front Range.
2.Denver TMS TherapyDenver, LoHi
Disclosure: Denver TMS Therapy shares ownership with this publication. See our full disclosure.
The central-Denver sister clinic to our #1 pick, with both ketamine pathways available under a psychiatrist's supervision: FDA-approved SPRAVATO® (esketamine) given in a certified, monitored setting, and physician-supervised ketamine therapy for patients who do not qualify for or prefer an alternative to the covered pathway. Founded by board-certified psychiatrist Dr. William Kromka, MD, the LoHi clinic also offers FDA-cleared TMS, accelerated iTBS, psychiatric evaluation, and medication management, so a patient evaluated for ketamine-based treatment has every other option in the same building. Insurance is accepted for SPRAVATO® and TMS, the clinic is TRICARE-authorized, and benefits are verified before treatment. Located at 2128 W 32nd Ave, 2nd Floor, Denver; the clinic answers at (720) 214-2770.
3.Denver Ketamine ClinicDenver, Washington Park West
Disclosure: Denver Ketamine Clinic shares ownership with this publication. See our full disclosure.
The Denver-proper clinic on this list built around ketamine-based treatment specifically. Founded by board-certified psychiatrist Dr. William Kromka, MD, it offers both pathways under one roof — physician-supervised ketamine therapy and FDA-approved SPRAVATO® (esketamine) in a certified, monitored setting — with FDA-cleared TMS, psychiatric evaluation, and medication management available if ketamine-based treatment is not the fit. The clinic is explicit about the distinction between the two pathways: what is FDA-approved, what is off-label, what insurance covers, and what each costs, before a patient decides. Insurance is accepted for SPRAVATO® and TMS, the clinic is TRICARE-authorized, and every session is monitored with a ride home arranged in advance. Located at 66 S Logan St near Washington Park; the clinic answers at (720) 221-8560.
4.Bluebird TMSGreenwood Village, DTC
Disclosure: Bluebird TMS shares ownership with this publication. See our full disclosure.
The south-metro option for both ketamine pathways: SPRAVATO® (esketamine) in a certified, monitored setting and physician-supervised ketamine therapy, at a Denver Tech Center clinic that serves Greenwood Village, Centennial, Englewood, and Littleton. Founded by board-certified psychiatrist Dr. William Kromka, MD, the clinic pairs ketamine-based treatment with FDA-cleared TMS, accelerated iTBS, psychiatric evaluation, and medication management, so the ride-home logistics of a monitored session are the only thing that changes between options. Insurance is accepted for SPRAVATO® and TMS, the clinic is TRICARE-authorized, and benefits are verified before you start. Located at 7447 E Berry Ave, Suite 150, Greenwood Village; the clinic answers at (720) 716-8469.
5.Axis Integrated Mental HealthWestminster
The northwest metro's strongest multi-path option: ketamine, SPRAVATO®, TMS, and general psychiatry in one organization, with an active patient-education library. For patients north and west of downtown wanting every option available under one roof, Axis is the area's most complete offering.
6.KlarisanaDenver
A dedicated ketamine-treatment organization with an established multi-location footprint and deep focus on ketamine-based care, including SPRAVATO®. For patients specifically seeking a ketamine-specialist practice with institutional experience in this exact modality, Klarisana is the metro's most established name.
7.Denver Wellness AssociatesDenver
An established psychiatry group offering SPRAVATO® within full psychiatric services across multiple metro locations — a strong fit for patients who want esketamine treatment embedded in an ongoing psychiatry relationship, with location convenience.
8.Ketamine DenverDenver
A dedicated ketamine clinic serving the metro with focused infusion-based care and south-metro accessibility. A solid specialist choice for patients on the self-pay infusion path.
9.Balanced Mental WellnessDenver
A ketamine-focused practice pairing treatment with psychiatric care, including ketamine-assisted approaches. A fit for patients drawn to a smaller-practice model.
10.Rocky Mountain Mind & BodyDenver
A ketamine provider with reach across Colorado, extending access beyond the immediate metro.
How to choose among them
The decision usually turns on four questions. First, which pathway fits: if you meet treatment-resistant depression criteria and have insurance, the certified SPRAVATO® route is usually the affordable one — which narrows you to certified centers (clinics 1–7 above). Second, supervision: every clinic on this list operates the in-clinic, monitored model — if you're comparing against at-home telehealth options, understand that supervision difference clearly before choosing. Third, what happens if this modality isn't the answer: clinics offering multiple treatment paths (1 through 5 especially) turn non-response into a next conversation instead of a new provider search. Fourth, logistics: session-plus-monitoring visits and the ride-home requirement make proximity matter more here than in most care. A brief consultation call — most of these clinics offer one — settles all four for your situation.